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Targeted Allele Detail
Symbol: Col11a2tm1Mne
Name: collagen, type XI, alpha 2; targeted mutation 1, Richard Mayne
MGI ID: MGI:2154689
Gene: Col11a2  Location: Chr17:34039437-34066685 bp, + strand  Genetic Position: Chr17, 17.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:71948
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin-resistance cassette was inserted between restriction sites in exons 27 and 28. A short, aberrant trancript was produced from the targeted allele, which could be detected by Northern blotting. However, translation of the full-length protein is predicted to result in a truncated protein, due to the presence of termination codons. (J:71948)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col11a2 Mutation:  2 strains or lines available
Original:  J:71948 Li SW, et al., Targeted disruption of Col11a2 produces a mild cartilage phenotype in transgenic mice: Comparison with the human disorder otospondylomegaepiphyseal dysplasia (OSMED). Dev Dyn. 2001 Oct;222(2):141-52
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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