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Itgb1tm1Lscd
Targeted Allele Detail
Nomenclature
Symbol: Itgb1tm1Lscd
Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 1, Caroline H Damsky
MGI ID: MGI:2154540
Synonyms: beta1-null, Itgbeta1-
Gene: Itgb1  Location: Chr8:128685654-128733200 bp, + strand  Genetic Position: Chr8, 76.09 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:28266
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A promoterless neomycin resistance gene fusion was inserted in-frame into exon 2 of the gene. (J:28266)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb1 Mutation:  12 strains or lines available
References
Original:  J:28266 Stephens LE, et al., Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev. 1995 Aug 1;9(15):1883-95
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory