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Wg2C57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Wg2C57BL/6J
Name: weight gain in high growth mice 2; C57BL/6J
MGI ID: MGI:2154526
QTL: Wg2  Location: unknown  Genetic Position: Chr2, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased growth rate compared to CAST/EiJ. (J:68441)
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Notes
Wg2 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68441

Authors indicated that enhanced growth rate in C57BL/6J-Cish2hg/Cish2hg mice may be modulated by other genes associated with growth. 1132 F2 mice from a cross between (C57BL/6J-Cish2hg/Cish2hg X CAST/EiJ)F1's yielded 274 +/+ , 596 hg/+ and 262 hg/hg mice withthe hg/hg used in a genome wide scan to find QTLs associated with growth rates. A total of 15 QTLs were mapped. QTLs for total weight gain (wg1 - wg4) mapped to mouse Chromosomes 2, 8, and 11, with wg1 and wg2 mapping to mouse chromosome 2. QTLS for total carcass protein (Carp1-Carp3) mapped to Chromosomes 2, 11 and 17. QTLs for total carcass ash weight (Cara1-Cara3) mapped to mouse Chromosomes 2, 11 and 17. QTLs for percent carcass fat (Carf1 and Carf2) mapped to mouse Chromosomes 5 and 9 and QTLS for femur length (Feml1-Feml3) mapped to mouse chromosomes 2, 9, and 17.

J:125711

Previously identified weight gain QTL Wg2 at 61 cM on mouse Chromosome 2 was further refined into four separate loci named Wg2a, Wg2b, Wg2c, and Wg2d by analysis of seven overlapping subcongenic lines derived from B6.CAST-(D2Mit329-D2Mit457). Wg2a, Wg2b,and Wg2c exhibit additive effects on body weight and/or fat pad mass, while Wg2d exhibits overdominance on fat pad mass. Body weight was recorded at 2, 3, 6, and 9 weeks of age. Fat pad weights were measured at sacrifice at 9 weeks of age.

Wg2a affects body weight and is located between D2Ucd15 (74.729 Mb) and D2Mit94 (79.976 Mb). Homozygosity for CAST/EiJ-derived alleles at Wg2a confers increased body weight at 6- and 9-weeks of age. This locus also shows suggestive linkage to all fat pads with CAST/EiJ-derived alleles conferring increased fat pad mass.

Wg2b maps to an interval flanked by D2Mit476 (86.245 Mb) and D2Mit420 (118.069 Mb). Homozygosity for CAST/EiJ-derived alleles at Wg2b confers decreased body weight at 6- and 9-weeks of age and decreasedfat pad mass for all fat pads. Wg5 (112 Mb) maps near this locus and the authors theorize it is likely identical to Wg2b.

Wg2c maps to an interval between D2Mit420 (118.069 Mb) and D2Mit107 (132.927 Mb). This locus is associated with fat pad mass. Homozygosity for CAST/EiJ-derived alleles at Wg2c confers increased retroperitoneal, gonadal, and total fat pad mass.

Heterozygosity for C57BL/6J- and CAST/EiJ-derived alleles at Wg2d confers decreased fat pad mass for all fat pads compared to either C57BL/6Jor CAST/EiJ homozygotes. Wg2d maps to an interval between D2Mit194 (143.623 Mb) and D2Mit196 (160.152 Mb).

References
Original:  J:68441 Corva PM, et al., Quantitative trait loci affecting growth in high growth (hg) mice. Mamm Genome. 2001 Apr;12(4):284-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory