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Cdx1tm1Pgr
Targeted Allele Detail
Nomenclature
Symbol: Cdx1tm1Pgr
Name: caudal type homeobox 1; targeted mutation 1, Peter Gruss
MGI ID: MGI:2154514
Synonyms: Cdx1-
Gene: Cdx1  Location: Chr18:61018862-61036199 bp, - strand  Genetic Position: Chr18, 34.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29755
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a TK-neomycin resistance cassette in reverse transcriptional orientation into exon 3 introduced a premature stop codon upstream of sequences that code for the carboxy terminus, which includes the recognition helix. Western blot analysis using antibodies raised to the amino terminus of the protein did not detect protein in intestine of homozygous mutant mice. (J:29755)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 33 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdx1 Mutation:  10 strains or lines available
References
Original:  J:29755 Subramanian V, et al., Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell. 1995 Nov 17;83(4):641-53
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory