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Immp2lTg(HLA-A/H2-D)2Enge
Transgenic Allele Detail
Nomenclature
Symbol: Immp2lTg(HLA-A/H2-D)2Enge
Name: IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae); transgene insertion 2, Victor H Engelhard
MGI ID: MGI:2153986
Synonyms: AAD mice
Gene: Immp2l  Location: Chr12:41074089-42002371 bp, + strand  Genetic Position: Chr12, 18.69 cM, cytoband B3
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA/Ca)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTransgenic mice express an interspecies hybrid class I MHC gene, AAD, which contains the alpha-1 and alpha-2 domains of the human HLA-A2.1 gene and the alpha-3 transmembrane and cytoplasmic domains of the murine H-2D gene, under the direction of the human HLA-A2.1 promoter. Immunodetection of the HLA-A2.1 recombinant transgene established that expression was at equivalent levels to endogenous murine class I molecules and to similar transgenic strains. Line 2 inserted into the gene at 41759331-41760601 (Build GRCm38/mm10) resulting in a 1270 bp deletion. The deletion results in a functional knock-out. Founder line 2 has a copy number of greater than 5. (J:31937)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Immp2l Mutation:  26 strains or lines available
References
Original:  J:31937 Newberg MH, et al., Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules. J Immunol. 1996 Apr 1;156(7):2473-80
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory