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Targeted Allele Detail
Symbol: Vcam1tm1Dmil
Name: vascular cell adhesion molecule 1; targeted mutation 1, David Milstone
MGI ID: MGI:2153831
Synonyms: Vcam1D4D, VCAM-1 D4D, Vcam1tm2Cyb
Gene: Vcam1  Location: Chr3:116109949-116129688 bp, - strand  Genetic Position: Chr3, 50.17 cM
Germline Transmission:  Earliest citation of germline transmission: J:69597
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance expression cassette replaced exon 6, which encodes Ig domain 4 and one of two alpha4 integrin binding sites. Expression of all isoforms of the transcript were reduced in homozygous mice compared to wild-type. (J:69597)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vcam1 Mutation:  23 strains or lines available
Original:  J:69597 Cybulsky MI, et al., A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest. 2001 May;107(10):1255-62
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory