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Abl2tm1Ajk
Targeted Allele Detail
Nomenclature
Symbol: Abl2tm1Ajk
Name: v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene); targeted mutation 1, Anthony J Koleske
MGI ID: MGI:2153719
Synonyms: arg -
Gene: Abl2  Location: Chr1:156558786-156649568 bp, + strand  Genetic Position: Chr1, 67.71 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51887
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe sequences encoding amino acids 287-320, corresponding to the N-terminal portion of the kinase domain, were replaced with a neomycin selection cassette. Western blot analysis demonstrated the absence of the protein in tissue extracts derived from homozygous mice. (J:51887)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 9 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abl2 Mutation:  41 strains or lines available
References
Original:  J:51887 Koleske AJ, et al., Essential roles for the Abl and Arg tyrosine kinases in neurulation. Neuron. 1998 Dec;21(6):1259-72
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory