About   Help   FAQ
Targeted Allele Detail
Symbol: Abl1tm1Mlg
Name: c-abl oncogene 1, non-receptor tyrosine kinase; targeted mutation 1, Richard C Mulligan
MGI ID: MGI:2153718
Synonyms: abl-, Abl2, ablm2, c-Abl-, c-abl2
Gene: Abl1  Location: Chr2:31688376-31804227 bp, + strand  Genetic Position: Chr2, 21.86 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:72875
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exon 5 and part of exon 6 was replaced by a neomycin resistance cassette. These sequences encode the N-terminal part of the tyrosine kinase domain, including the nucleotide and ATP binding sites. (J:72875)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Abl1 Mutation:  56 strains or lines available
Original:  J:72875 Tybulewicz VL, et al., Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell. 1991 Jun 28;65(7):1153-63
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.15
The Jackson Laboratory