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Targeted Allele Detail
Symbol: Bgntm1Mfy
Name: biglycan; targeted mutation 1, Marian F Young
MGI ID: MGI:2153057
Synonyms: Bgn-/0, Bgn0, bgn-KO
Gene: Bgn  Location: ChrX:73483602-73495933 bp, + strand  Genetic Position: ChrX, 37.33 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:49647
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 2. Northern blot analysis demonstrated that no transcript was detectable in hemizyogous male mice and western blot analysis showed that the protein was not expressed in hemizygous male mice. (J:49647)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bgn Mutation:  3 strains or lines available
Phenotypic Similarity to Human Syndrome: Preterm premature rupture of fetal membranes (PPROM; J:180914) in mice homozygous for Bgntm1Mfy and Dcntm1Ioz

Phenotypic Similarity to Human Syndrome: Ehlers-Danlos syndrome, progeroid type in mice homozygous or hemizygous for for Bgntm1Mfy and homozygous for Dcntm1Ioz (J:91512).

Phenotypic Similarity to Human Syndrome: Temporomandibular Joint Osteoarthritis J:112779, J:117908, J:226593 in mice homozygous or hemizygous for Bgntm1Mfy and homozygous for Fmodtm1Aol.

Original:  J:49647 Xu T, et al., Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice. Nat Genet. 1998 Sep;20(1):78-82
All:  48 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
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