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Itga7tm1Umr
Targeted Allele Detail
Nomenclature
Symbol: Itga7tm1Umr
Name: integrin alpha 7; targeted mutation 1, Ulrike Mayer
MGI ID: MGI:2153005
Synonyms: alpha7-
Gene: Itga7  Location: Chr10:128933813-128958277 bp, + strand  Genetic Position: Chr10, 77.2 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43840
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 1kb genomic fragment containing exon 1 sequences encoding the signal sequence and first 107bp of the mature protein. Mutant transcripts were detected by Northern blot and RT-PCR analysis in muscle derived from homozygous mice, but these transcripts do not contain sequences associated with exon 1. FACS analysis on myoblasts isolated from homozygous mice demonstrated an absence of the protein and immunohistochemistry on frozen muscle sections demonstrated that no protein was detectable. (J:43840)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga7 Mutation:  9 strains or lines available
References
Original:  J:43840 Mayer U, et al., Absence of integrin alpha 7 causes a novel form of muscular dystrophy. Nat Genet. 1997 Nov;17(3):318-23
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory