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Targeted Allele Detail
Symbol: Fgatm1Jld
Name: fibrinogen alpha chain; targeted mutation 1, Jay L Degen
MGI ID: MGI:2152976
Synonyms: Aalpha-, fbg-, Fbgalpha-, Fg-, Fib-, Fib0
Gene: Fga  Location: Chr3:83026076-83033627 bp, + strand  Genetic Position: Chr3, 36.96 cM, cytoband F1
Germline Transmission:  Earliest citation of germline transmission: J:28436
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsAn HPRT minigene cassette was inserted into exon 1 in sequences corresponding to the the signal peptide sequence. Transcripts from this allele were not detected in total liver RNA derived from homozygous mice and an in vitro clotting assay demonstrated that no functional fibrinogen protein was present in plasma derived from homozygous mice. (J:28436)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fga Mutation:  25 strains or lines available
Original:  J:28436 Suh TT, et al., Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Genes Dev. 1995 Aug 15;9(16):2020-33
All:  56 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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