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Col9a1tm1Jae
Targeted Allele Detail
Nomenclature
Symbol: Col9a1tm1Jae
Name: collagen, type IX, alpha 1; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:2152964
Gene: Col9a1  Location: Chr1:24177610-24252684 bp, + strand  Genetic Position: Chr1, 9.95 cM
Histology of knee joint articular cartilage of wild-type control and Col9a1tm1Jae/Col9a1tm1Jae mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:18628
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 8 in reverse transcriptional orientation relative to the gene. Northern blot analysis on RNA derived from E17.5 homozygous embryos demonstrated that no detectable transcript was produced from this allele. Western blot analysis on extracts of rib cage and vertebral column from homozygous mice confirmed that no stable encoded protein was present. (J:18628)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 10 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col9a1 Mutation:  3 strains or lines available
References
Original:  J:18628 Fassler R, et al., Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease. Proc Natl Acad Sci U S A. 1994 May 24;91(11):5070-4
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory