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Pdx1tm1Ted
Targeted Allele Detail
Summary
Symbol: Pdx1tm1Ted
Name: pancreatic and duodenal homeobox 1; targeted mutation 1, Thomas Edlund
MGI ID: MGI:2152755
Synonyms: Ipf1-, pdx1-
Gene: Pdx1  Location: Chr5:147206907-147212658 bp, + strand  Genetic Position: Chr5, 86.84 cM
Alliance: Pdx1tm1Ted page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:20779
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 2, deleting sequences that encode the homeodomain, the splice acceptor site, and flanking intron sequences. Whole-mount immunohistochemical studies did not detect protein in homozygous mutant embryos. (J:20779)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 14 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdx1 Mutation:  28 strains or lines available
References
Original:  J:20779 Jonsson J, et al., Insulin-promoter-factor 1 is required for pancreas development in mice. Nature. 1994 Oct 13;371(6498):606-9
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/26/2022
MGI 6.22
The Jackson Laboratory