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Targeted Allele Detail
Symbol: Gnastm1Gwa
Name: GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; targeted mutation 1, Gary Wand
MGI ID: MGI:2152744
Synonyms: GnasE1-
Gene: Gnas  Location: Chr2:174284320-174346744 bp, + strand  Genetic Position: Chr2, 97.89 cM, cytoband E1-H3
Subcutaneous ossifications in Gnastm1Gwa/Gnas+ mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:70175
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced 0.5kb of sequence containing the ATG codon and extending through an NruI site in intron 1. Quantitative immunoblot studies showed protein levels in multiple brain regions of mice heterozygous for this allele were significantly reduced relative to wild-type. (J:70175)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnas Mutation:  9 strains or lines available
Original:  J:70175 Wand G, et al., The cAMP-protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol. J Neurosci. 2001 Jul 15;21(14):5297-303
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory