Mgat5^tm1Jwd
Targeted Allele Detail

Summary

• Symbol: Mgat5^tm1Jwd
• Name: mannoside acetylglucosaminyltransferase 5; targeted mutation 1, James W Dennis
• MGI ID: MGI:2152619
• Synonyms: GnTV^-, Mgat5^-
• Gene: Mgat5 Location: Chr1:127132450-127413760 bp, + strand Genetic Position: Chr1, 55.71 cM
• Alliance: Mgat5^tm1Jwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60960
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• A LacZ and neomycin resistance cassette replaced part of exon 1. (J:60960)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mgat5^tm1Jwd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mgat5 Mutation: 65 strains or lines available

References

• Original: J:60960 Granovsky M, et al., Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nat Med. 2000 Mar;6(3):306-12
• All: 29 reference(s)