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Map1btm1Noh
Targeted Allele Detail
Nomenclature
Symbol: Map1btm1Noh
Name: microtubule-associated protein 1B; targeted mutation 1, Nobutaka Hirokawa
MGI ID: MGI:2152588
Synonyms: MAPP1B-, R21
Gene: Map1b  Location: Chr13:99421464-99516602 bp, - strand  Genetic Position: Chr13, 52.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41889
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a PGK-neomycin resistance cassette into the first coding exon disrupted the light-chain binding domain of the gene. The predicted truncated product of this allele is 11 amino acids long. Immunoblot analyses of brain using antisera to the microtubule-binding domain, to the carboxy-terminal imperfect repeats region, and to phosphorylated protein, detected little or no wild-type protein in homozygous mutant mice at postnatal day 4 and at 8 weeks of age. (J:41889)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map1b Mutation:  45 strains or lines available
References
Original:  J:41889 Takei Y, et al., Delayed development of nervous system in mice homozygous for disrupted microtubule-associated protein 1B (MAP1B) gene. J Cell Biol. 1997 Jun 30;137(7):1615-26
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory