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Targeted Allele Detail
Symbol: Map2tm1Noh
Name: microtubule-associated protein 2; targeted mutation 1, Nobutaka Hirokawa
MGI ID: MGI:2152587
Synonyms: map2-
Gene: Map2  Location: Chr1:66175273-66442583 bp, + strand  Genetic Position: Chr1, 33.49 cM
Germline Transmission:  Earliest citation of germline transmission: J:71900
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin resistance cassette disrupted the exon that encodes the first microtubule-binding repeat. This exon corresponds to exon 15 of the human MAP2 gene. Western analysis did not detect protein in brain of eight week old homozygous mutant mice. (J:71900)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map2 Mutation:  2 strains or lines available
Original:  J:71900 Teng J, et al., Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization. J Cell Biol. 2001 Oct 1;155(1):65-76
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory