Dmd^tm1Smh
Targeted Allele Detail

Summary

• Symbol: Dmd^tm1Smh
• Name: dystrophin, muscular dystrophy; targeted mutation 1, Stephen DM Brown
• MGI ID: MGI:2152585
• Gene: Dmd Location: ChrX:81992476-84249747 bp, + strand Genetic Position: ChrX, 38.38 cM, cytoband C
• Alliance: Dmd^tm1Smh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72373
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A promoterless lacZ reporter gene was placed in-frame in exon 62 and included stop codons and poly(A) signals following the lacZ gene. A DMD-beta galactosidase fusion protein is expressed from this allele. (J:72373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmd Mutation: 167 strains or lines available

References

• Original: J:72373 Maconochie MK, et al., The cysteine-rich and C-terminal domains of dystrophin are not required for normal costameric localization in the mouse. Transgenic Res. 1996 Mar;5(2):123-30
• All: 1 reference(s)