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Targeted Allele Detail
Symbol: Adora2atm1Map
Name: adenosine A2a receptor; targeted mutation 1, Marc Parmentier
MGI ID: MGI:2152583
Synonyms: A2AAR-, A2AKO, A2aR-
Gene: Adora2a  Location: Chr10:75316877-75334784 bp, + strand  Genetic Position: Chr10, 38.52 cM, cytoband B5.3
Germline Transmission:  Earliest citation of germline transmission: J:42276
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 1 was replaced with a neomycin selection cassette. Northern blotting and in situ hybridization experiments confirmed that no detectable transcript is produced from this allele. (J:42276)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adora2a Mutation:  24 strains or lines available
Original:  J:42276 Ledent C, et al., Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor [see comments]. Nature. 1997 Aug 14;388(6643):674-8
All:  63 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory