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Targeted Allele Detail
Symbol: Xrcc5tm1Nus
Name: X-ray repair complementing defective repair in Chinese hamster cells 5; targeted mutation 1, Andre Nussenzweig
MGI ID: MGI:2152542
Synonyms: Ku80-, Ku86-, Xrcc5tm1Gcl
Gene: Xrcc5  Location: Chr1:72307427-72394952 bp, + strand  Genetic Position: Chr1, 36.5 cM, cytoband E
Small body size, small spleen and absent thymus in Nhej1tm1Fwa/Nhej1tm1Fwa Xrcc5tm1Nus/Xrcc5tm1Nus mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:72368
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced 3.4 kb of the gene, including 100 bp of the promoter region. (J:72368)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Xrcc5 Mutation:  28 strains or lines available
Original:  J:72368 Nussenzweig A, et al., Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature. 1996 Aug 8;382(6591):551-5
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory