Xrcc5^tm1Nus
Targeted Allele Detail

Summary

• Symbol: Xrcc5^tm1Nus
• Name: X-ray repair complementing defective repair in Chinese hamster cells 5; targeted mutation 1, Andre Nussenzweig
• MGI ID: MGI:2152542
• Synonyms: Ku80-, Ku86-, Xrcc5^tm1Gcl
• Gene: Xrcc5 Location: Chr1:72346586-72434111 bp, + strand Genetic Position: Chr1, 36.5 cM, cytoband E
• Alliance: Xrcc5^tm1Nus page

Small body size, small spleen and absent thymus in Nhej1^tm1Fwa/Nhej1^tm1Fwa Xrcc5^tm1Nus/Xrcc5^tm1Nus mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72368
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced 3.4 kb of the gene, including 100 bp of the promoter region. (J:72368)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Xrcc5^tm1Nus

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xrcc5 Mutation: 70 strains or lines available

References

• Original: J:72368 Nussenzweig A, et al., Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature. 1996 Aug 8;382(6591):551-5
• All: 37 reference(s)