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Targeted Allele Detail
Symbol: Grb2tm1Paw
Name: growth factor receptor bound protein 2; targeted mutation 1, Tony Pawson
MGI ID: MGI:2152451
Synonyms: deltaGrb2, Grb2-
Gene: Grb2  Location: Chr11:115644045-115708597 bp, - strand  Genetic Position: Chr11, 80.91 cM
Germline Transmission:  Earliest citation of germline transmission: J:51424
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exons 2 and 3 was replaced with a vector containing a neomycin selection cassette by homologous recombination. Immunoprecipitation and western blotting experiments on cell lysates derived from homozygous mice confirmed that no detectable protein was made from this allele. (J:51424)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grb2 Mutation:  38 strains or lines available
Original:  J:51424 Cheng AM, et al., Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell. 1998 Dec 11;95(6):793-803
All:  12 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory