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Hoxa13tm1.1Mrc
Targeted Allele Detail
Nomenclature
Symbol: Hoxa13tm1.1Mrc
Name: homeobox A13; targeted mutation 1.1, Mario R Capecchi
MGI ID: MGI:2152356
Synonyms: Hoxa13GFP
Gene: Hoxa13  Location: Chr6:52258853-52260880 bp, - strand  Genetic Position: Chr6, 25.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72301
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsGFP was inserted in-frame into exon 2. In this derivative of Hoxa13tm1Mrc, Cre-mediated recombination in the germline removed an adjacent floxed neomycin resistance cassette. The expression pattern in E10.5-E13.5 embryos of a Hoxa13-GFP fusion protein from this allele recapitulates the published Hoxa13 mRNA expression pattern. (J:72301)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 187 assay results
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa13 Mutation:  22 strains or lines available
References
Original:  J:72301 Stadler HS, et al., Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs. Development. 2001 Nov;128(21):4177-88
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory