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Esr2tm1Unc
Targeted Allele Detail
Summary
Symbol: Esr2tm1Unc
Name: estrogen receptor 2 (beta); targeted mutation 1, University of North Carolina
MGI ID: MGI:2152217
Synonyms: BERKO, BERKOChapel Hill, betaERKO, beta-ERKO, Erb-, ERbeta-, ERbetaKO
Gene: Esr2  Location: Chr12:76167193-76224033 bp, - strand  Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
Alliance: Esr2tm1Unc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51663
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 3 of the gene, introducing a stop codon and resulting in premature termination of translation of the Esr2 mRNA. Immunocytochemistry of ovary from homozygous mutant females showed no detectable Esr2 protein. (J:51663)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 27 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 39 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Esr2tm1Unc
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Esr2 Mutation:  32 strains or lines available
Notes
ES cell line = BK4, which is derived from a subclone of E14TG2a.
References
Original:  J:51663 Krege JH, et al., Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15677-82
All:  198 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory