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Targeted Allele Detail
Symbol: Esr2tm1Unc
Name: estrogen receptor 2 (beta); targeted mutation, University of North Carolina
MGI ID: MGI:2152217
Synonyms: BERKO, BERKOChapel Hill, betaERKO, beta-ERKO, Erb-, ERbeta-, ERbetaKO
Gene: Esr2  Location: Chr12:76120419-76177259 bp, - strand  Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
Germline Transmission:  Earliest citation of germline transmission: J:51663
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 3 of the gene, introducing a stop codon and resulting in premature termination of translation of the Esr2 mRNA. Immunocytochemistry of ovary from homozygous mutant females showed no detectable Esr2 protein. (J:51663)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 34 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Esr2 Mutation:  24 strains or lines available
ES cell line = BK4, which is derived from a subclone of E14TG2a.
Original:  J:51663 Krege JH, et al., Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15677-82
All:  173 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory