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Ptentm1Rps
Targeted Allele Detail
Nomenclature
Symbol: Ptentm1Rps
Name: phosphatase and tensin homolog; targeted mutation 1, Ramon Parsons
MGI ID: MGI:2151804
Synonyms: Pten-
Gene: Pten  Location: Chr19:32757497-32826160 bp, + strand  Genetic Position: Chr19, 28.14 cM
Neoplasia of multiple organs in Ptentm1Rps/Pten+ mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53065
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Part of exon 5 was replaced with a vector containing the neomycin resistance gene. (J:53065)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  36 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Melanoma J:155731

References
Original:  J:53065 Podsypanina K, et al., Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1563-8
All:  59 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory