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Ptentm1Rps
Targeted Allele Detail
Summary
Symbol: Ptentm1Rps
Name: phosphatase and tensin homolog; targeted mutation 1, Ramon Parsons
MGI ID: MGI:2151804
Synonyms: Pten-
Gene: Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM
Alliance: Ptentm1Rps page
Neoplasia of multiple organs in Ptentm1Rps/Pten+ mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53065
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Part of exon 5 was replaced with a vector containing the neomycin resistance gene. (J:53065)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 10 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ptentm1Rps
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  81 strains or lines available
References
Original:  J:53065 Podsypanina K, et al., Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1563-8
All:  83 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory