About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 8:00 AM ET Wed, September 18.
Targeted Allele Detail
Symbol: Scxtm2Eno
Name: scleraxis; targeted mutation 2, Eric N Olson
MGI ID: MGI:2151296
Synonyms: scleraxis -
Gene: Scx  Location: Chr15:76457452-76459458 bp, + strand  Genetic Position: Chr15, 35.92 cM
Mouse Generated:  Earliest citation of chimera generation: J:55991
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S7/SvEvBrd and C57BL/6 and Swiss
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-hygromycin resistance cassette replaced exon 1 of the wild-type Scx allele in heterozygous ES cells (Gt(ROSA)26Sor+/- Scxtm1Eno-+/-). Injection of lacZ-marked Scxtm1Eno/Scxtm2Eno ES cells into wild-type blastocysts resulted in chimeric embryos. (J:55991)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scx Mutation:  2 strains or lines available
Original:  J:55991 Brown D, et al., Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis. Development. 1999 Oct;126(19):4317-29
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory