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Scxtm2Eno
Targeted Allele Detail
Nomenclature
Symbol: Scxtm2Eno
Name: scleraxis; targeted mutation 2, Eric N Olson
MGI ID: MGI:2151296
Synonyms: scleraxis -
Gene: Scx  Location: Chr15:76457438-76459468 bp, + strand  Genetic Position: Chr15, 35.92 cM
Mutation
origin
Mouse Generated:  Earliest citation of chimera generation: J:55991
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S7/SvEvBrd and C57BL/6 and Swiss
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-hygromycin resistance cassette replaced exon 1 of the wild-type Scx allele in heterozygous ES cells (Gt(ROSA)26Sor+/- Scxtm1Eno-+/-). Injection of lacZ-marked Scxtm1Eno/Scxtm2Eno ES cells into wild-type blastocysts resulted in chimeric embryos. (J:55991)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scx Mutation:  4 strains or lines available
References
Original:  J:55991 Brown D, et al., Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis. Development. 1999 Oct;126(19):4317-29
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory