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Sema3ctm1.1Jra
Targeted Allele Detail
Nomenclature
Symbol: Sema3ctm1.1Jra
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; targeted mutation 1.1, Jonathan A Raper
MGI ID: MGI:2150759
Synonyms: Sema3C-, Sema3C(neoout)
Gene: Sema3c  Location: Chr5:17574816-17730268 bp, + strand  Genetic Position: Chr5, 7.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71240
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThis allele is a derivative of Sema3ctm1Jra in which the neomycin resistance gene was removed by Cre mediated recombination by crossing mice that carry the Sema3c allele to mice that express Cre recombinase in the germ cell. mRNA in homozygous mutant E12.5 embryos was barely detectable by in situ hybridization. RT-PCR analysis of these embryos detected transcript from regions 5' and 3' of the targeted sequences, but did not detect transcript from a region internal to the targeted sequences. (J:71240)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 18 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sema3c Mutation:  2 strains or lines available
References
Original:  J:71240 Feiner L, et al., Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption. Development. 2001 Aug;128(16):3061-70
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory