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Fgfr1tm1Led
Targeted Allele Detail
Nomenclature
Symbol: Fgfr1tm1Led
Name: fibroblast growth factor receptor 1; targeted mutation 1, Philip Leder
MGI ID: MGI:2150650
Synonyms: Fgfr-1ex4
Gene: Fgfr1  Location: Chr8:25513654-25575718 bp, + strand  Genetic Position: Chr8, 14.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:22118
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette disrupted exon 4 of the gene, introducing stop codons in the three reading frames and truncating the coding sequence immediately after the Ig2 domain. (J:22118)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr1 Mutation:  206 strains or lines available
References
Original:  J:22118 Deng CX, et al., Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev. 1994 Dec 15;8(24):3045-57
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory