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Hoxa13tm1Ipc
Targeted Allele Detail
Nomenclature
Symbol: Hoxa13tm1Ipc
Name: homeobox A13; targeted mutation 1, I Pierre Chambon
MGI ID: MGI:2150506
Gene: Hoxa13  Location: Chr6:52258853-52260880 bp, - strand  Genetic Position: Chr6, 25.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36214
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into sequences encoding the homeobox domain; this mutation generates a disruption of the protein sequence after the 34th amino acid, corresponding to the second alpha helix of the homeodomain. (J:36214)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 27 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa13 Mutation:  22 strains or lines available
References
Original:  J:36214 Fromental-Ramain C, et al., Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod. Development. 1996 Oct;122(10):2997-3011
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory