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Targeted Allele Detail
Symbol: Eya1tm1Rilm
Name: EYA transcriptional coactivator and phosphatase 1; targeted mutation 1, Richard Maas
MGI ID: MGI:2150426
Synonyms: Eya1-
Gene: Eya1  Location: Chr1:14168954-14310235 bp, - strand  Genetic Position: Chr1, 4.31 cM
Spectrum of abnormalities of great artery patterning in mice with null mutation of one or both copies of Six1tm1Mair and Eya1tm1Rilm

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:57313
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin cassette replaced exons 10-13, encoding 153 residues of the Eya domain. (J:57313)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 93 assay results
In Structures Affected by this Mutation: 61 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Eya1 Mutation:  4 strains or lines available
Original:  J:57313 Xu PX, et al., Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet. 1999 Sep;23(1):113-7
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory