Slc7a2^tm1Clm
Targeted Allele Detail

Summary

• Symbol: Slc7a2^tm1Clm
• Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 2; targeted mutation 1, Carol L MacLeod
• MGI ID: MGI:2150359
• Synonyms: Cat2 -
• Gene: Slc7a2 Location: Chr8:41315404-41375107 bp, + strand Genetic Position: Chr8, 23.89 cM
• Alliance: Slc7a2^tm1Clm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69414
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced 1.9 kb of sequence, including exon 2. (J:69414)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc7a2 Mutation: 50 strains or lines available

References

• Original: J:69414 Nicholson B, et al., Sustained nitric oxide production in macrophages requires the arginine transporter CAT2. J Biol Chem. 2001 May 11;276(19):15881-5
• All: 12 reference(s)