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Targeted Allele Detail
Symbol: Fgf8tm1.2Mrt
Name: fibroblast growth factor 8; targeted mutation 1.2, Gail R Martin
MGI ID: MGI:2150346
Synonyms: Fgf8delta2,3n
Gene: Fgf8  Location: Chr19:45736798-45742915 bp, - strand  Genetic Position: Chr19, 38.75 cM, cytoband C3-D
Germline Transmission:  Earliest citation of germline transmission: J:45909
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele is a derivative of Fgf8tm1.1Mrt in which mice carrying this allele were mated to beta-actin cre mice, which resulted in heterozygous offspring carrying a recombined Fgf8 allele in which exons 2 and 3 were deleted. (J:45909)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 25 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf8 Mutation:  10 strains or lines available
One of three alleles produced using a targeting construct capable of inducing different allelic variants when mated to mice that express cre, flp, or both. Referred to in the literature as Fgf8delta2,3n, this allele lacks exons 2 and 3 and is a presumed null. Heterozygotes are normal. Homozygotes are smaller than littermates and lack all embryonic mesoderm- derived structures including heart and somites. This mutation causes lethality by embryonic day 10.5 (J:45909).
Original:  J:45909 Meyers EN, et al., An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet. 1998 Feb;18(2):136-41
All:  15 reference(s)

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MGI 6.12
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