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Targeted Allele Detail
Symbol: Dpp4tm1Nwa
Name: dipeptidylpeptidase 4; targeted mutation 1, Nicolai Wagtmann
MGI ID: MGI:2150161
Synonyms: CD26-, DP-IV-
Gene: Dpp4  Location: Chr2:62330073-62412231 bp, - strand  Genetic Position: Chr2, 35.85 cM, cytoband C2-D
Germline Transmission:  Earliest citation of germline transmission: J:62709
Parent Cell Line:  BL/6-III (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a 2.3kb segment of the gene, including part of the promoter and all of exons 1 and 2, which encode the cytoplasmic and transmembrane domains of the protein. Flow cytometric analysis of thymocytes from homozygous mutantt mice stained with anti-Dpp4 mAb showed no protein expression. ELISA measurements showed undetectable protein concentrations in the plasma of homozygous mutant mice. (J:62709)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dpp4 Mutation:  43 strains or lines available
Original:  J:62709 Marguet D, et al., Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6874-9
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory