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Targeted Allele Detail
Symbol: Aqp3tm1Ask
Name: aquaporin 3; targeted mutation 1, Alan S Verkman
MGI ID: MGI:2150021
Synonyms: AQP3-
Gene: Aqp3  Location: Chr4:41092722-41098183 bp, - strand  Genetic Position: Chr4, 20.94 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:61675
Parent Cell Line:  CB1-4 (ES Cell)
Strain of Origin:  C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.3kb neomycin resistance cassette replaced parts of exons 2 and 3 of the gene. Northern blots of kidneys from homozygous mutant mice had no detectable Aqp3 transcript. Immunofluorescence analysis of fixed frozen kidney sections from homozygous mutant mice had no detectable Aqp3 protein. (J:61675)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp3 Mutation:  20 strains or lines available
Original:  J:61675 Ma T, et al., Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4386-91
All:  28 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory