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Cdk4tm1Kiyo
Targeted Allele Detail
Nomenclature
Symbol: Cdk4tm1Kiyo
Name: cyclin-dependent kinase 4; targeted mutation 1, Hiroaki Kiyokawa
MGI ID: MGI:2149587
Synonyms: CDK4-
Gene: Cdk4  Location: Chr10:127063534-127067920 bp, + strand  Genetic Position: Chr10, 74.5 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57854
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced a 3' portion of exon 1 and all of exons 2 - 5. Western blot analysis on extracts derived from fibroblasts of homozygous mice detected no encoded protein. (J:57854)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 37 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdk4 Mutation:  42 strains or lines available
References
Original:  J:57854 Tsutsui T, et al., Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity. Mol Cell Biol. 1999 Oct;19(10):7011-9
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory