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Pik3r1tm1Tka
Targeted Allele Detail
Nomenclature
Symbol: Pik3r1tm1Tka
Name: phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); targeted mutation 1, Takashi Kadowaki
MGI ID: MGI:2149414
Synonyms: p85alpha-, PI3K p85alpha-, Pi3kr1-
Gene: Pik3r1  Location: Chr13:101680563-101768217 bp, - strand  Genetic Position: Chr13, 53.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52576
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced the first exon, exon 1A, of the gene. Functional analysis showed that deletion of this exon, which contains the initiation codon, abolished expression of the p85a variant, while not disrupting expression of the p50a or p55a splicing variants. (J:52576)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pik3r1 Mutation:  20 strains or lines available
References
Original:  J:52576 Terauchi Y, et al., Increased insulin sensitivity and hypoglycaemia in mice lacking the P85 alpha subunit of phosphoinositide 3- kinase. Nat Genet. 1999 FEB;21(2):230-235
All:  44 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory