Cebpb^tm1Vpo
Targeted Allele Detail

Summary

• Symbol: Cebpb^tm1Vpo
• Name: CCAAT/enhancer binding protein beta; targeted mutation 1, Valeria Poli
• MGI ID: MGI:2149329
• Synonyms: Cebpb-, C/EBPb-, C/EBPbeta^-
• Gene: Cebpb Location: Chr2:167530835-167532338 bp, + strand Genetic Position: Chr2, 87.58 cM
• Alliance: Cebpb^tm1Vpo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25215
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An MC1-neocassette replaced the carboxy-terminal part of the gene, which encodes the leucine zipper and part of the basic domain. Generation of a null allele was confirmed by Western blots of hepatic tissue nuclear extracts. (J:25215)

Disease models

Expression

In Structures Affected by this Mutation:

22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cebpb Mutation: 23 strains or lines available

Notes

Mice homozygous for this targeted mutation exhibit a pathology that is almost identical to multicentric Castleman's disease in human patients, characterized by splenomegaly, peripheral lymphoadenopathy, enhanced hematopoiesis, and deregulated IL-6 production (J:25215).

References

• Original: J:25215 Screpanti I, et al., Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice [published erratum appears in EMBO J 1995 Jul 17;14(14):3596]. EMBO J. 1995 May 1;14(9):1932-41
• All: 52 reference(s)