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Psen1tm1Bdes
Targeted Allele Detail
Nomenclature
Symbol: Psen1tm1Bdes
Name: presenilin 1; targeted mutation 1, Bart de Strooper
MGI ID: MGI:2149116
Synonyms: PS1-
Gene: Psen1  Location: Chr12:83688563-83735199 bp, + strand  Genetic Position: Chr12, 38.84 cM
Psen1tm1Bdes/Psen1tm1Bdes Psen2tm1Bdes/Psen2tm1Bdes embryos display severe growth retardation at E9.5

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71037
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Psen1 Mutation:  22 strains or lines available
References
Original:  J:71037 De Strooper B, et al., Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 1998 Jan 22;391(6665):387-90
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory