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Ephx2tm1Gonz
Targeted Allele Detail
Nomenclature
Symbol: Ephx2tm1Gonz
Name: epoxide hydrolase 2, cytoplasmic; targeted mutation 1, Frank Gonzalez
MGI ID: MGI:2149064
Synonyms: sEH-, sEH-null
Gene: Ephx2  Location: Chr14:66084374-66124500 bp, - strand  Genetic Position: Chr14, 34.36 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71007
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin resistance cassette into the translation initiation site in the first exon. Northern analysis did not detect transcript in liver from homozygous mutant mice. Immunoblot analysis did not detect protein in cytosolic fractions of liver from homozygous mutant mice. (J:71007)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ephx2 Mutation:  6 strains or lines available
References
Original:  J:71007 Sinal CJ, et al., Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation. J Biol Chem. 2000 Dec 22;275(51):40504-10
All:  82 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory