Ephx2^tm1Gonz
Targeted Allele Detail

Summary

• Symbol: Ephx2^tm1Gonz
• Name: epoxide hydrolase 2, cytoplasmic; targeted mutation 1, Frank Gonzalez
• MGI ID: MGI:2149064
• Synonyms: sEH^-, sEH-null
• Gene: Ephx2 Location: Chr14:66321823-66361949 bp, - strand Genetic Position: Chr14, 34.36 cM, cytoband D
• Alliance: Ephx2^tm1Gonz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71007
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into the translation initiation site in the first exon. Northern analysis did not detect transcript in liver from homozygous mutant mice. Immunoblot analysis did not detect protein in cytosolic fractions of liver from homozygous mutant mice. (J:71007)

Tumor Data

List all tumor models in MMHCdb carrying Ephx2^tm1Gonz

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ephx2 Mutation: 39 strains or lines available

References

• Original: J:71007 Sinal CJ, et al., Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation. J Biol Chem. 2000 Dec 22;275(51):40504-10
• All: 94 reference(s)