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Ctnnb1tm4Wbm
Targeted Allele Detail
Nomenclature
Symbol: Ctnnb1tm4Wbm
Name: catenin (cadherin associated protein), beta 1; targeted mutation 4, Walter Birchmeier
MGI ID: MGI:2148594
Synonyms: beta-cateninflox, beta-cateninlox, beta-cat lox, beta-catloxEx3-6, Ctnnb1fl
Gene: Ctnnb1  Location: Chr9:120933400-120960507 bp, + strand  Genetic Position: Chr9, 72.19 cM
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm Tg(Pdx1-cre)6Tuv/? pancreata display extensive loss of exocrine tissue

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69463
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted into the second intron and a loxP-flanked neomycin selection cassette was inserted into the sixth intron. The neomycin cassette was removed by transient expression of Cre recombinase in ES cells prior to the production of chimeric mice, leaving two loxP sites that flank exons 3-6 in the final allele. Northern blot analysis demonstrated that a transcript of wild-type length is produced from this allele, and western blot analysis confirmed that a normal protein is made. (J:69463)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 22 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ctnnb1 Mutation:  21 strains or lines available
References
Original:  J:69463 Huelsken J, et al., beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell. 2001 May 18;105(4):533-45
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory