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Targeted Allele Detail
Symbol: Ctnnb1tm3Wbm
Name: catenin (cadherin associated protein), beta 1; targeted mutation 3, Walter Birchmeier
MGI ID: MGI:2148593
Synonyms: beta-catlacZ(hygro)
Gene: Ctnnb1  Location: Chr9:120933400-120960507 bp, + strand  Genetic Position: Chr9, 72.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:60391
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA lacZ gene was inserted in-frame into the gene, fused to the endogenous transcription start site. A hygromycin selection cassette followed the lacZ gene. Northern blot analysis on RNA derived from homozygous ES cells demonstrated that no detectable transcript was produced from this allele, and western blot analysis on homozygous ES cells confirmed that no stable protein is produced from this allele (data not shown). (J:60391)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctnnb1 Mutation:  21 strains or lines available
Original:  J:60391 Huelsken J, et al., Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol. 2000 Feb 7;148(3):567-78
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory