Mpg^tm1Rhe
Targeted Allele Detail

Summary

• Symbol: Mpg^tm1Rhe
• Name: N-methylpurine-DNA glycosylase; targeted mutation 1, Rhoderick H Elder
• MGI ID: MGI:2148592
• Synonyms: APNG^-
• Gene: Mpg Location: Chr11:32176505-32182700 bp, + strand Genetic Position: Chr11, 18.83 cM
• Alliance: Mpg^tm1Rhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50033
• Parent Cell Line: MESC 20 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 1 and 2. RT-PCR studies on RNA derived from testes of homozygous mutant mice demonstrated that no detectable transcript was expressed from this allele. (J:50033)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mpg^tm1Rhe

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpg Mutation: 16 strains or lines available

References

• Original: J:50033 Elder RH, et al., Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate. Mol Cell Biol. 1998 Oct;18(10):5828-37
• All: 5 reference(s)