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Targeted Allele Detail
Symbol: Mpgtm1Rhe
Name: N-methylpurine-DNA glycosylase; targeted mutation 1, Rhoderick H Elder
MGI ID: MGI:2148592
Synonyms: APNG-
Gene: Mpg  Location: Chr11:32226505-32232700 bp, + strand  Genetic Position: Chr11, 18.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:50033
Parent Cell Line:  MESC 20 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced exons 1 and 2. RT-PCR studies on RNA derived from testes of homozygous mutant mice demonstrated that no detectable transcript was expressed from this allele. (J:50033)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mpg Mutation:  11 strains or lines available
Original:  J:50033 Elder RH, et al., Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate. Mol Cell Biol. 1998 Oct;18(10):5828-37
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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