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Cdh5tm1Pec
Targeted Allele Detail
Nomenclature
Symbol: Cdh5tm1Pec
Name: cadherin 5; targeted mutation 1, Peter Carmeliet
MGI ID: MGI:2148547
Synonyms: VECneo
Gene: Cdh5  Location: Chr8:104101625-104144511 bp, + strand  Genetic Position: Chr8, 53.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:56509
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA stop codon was introduced into the coding sequence in front of the sequences encoding the 82 carboxy-terminal residues. A loxP-flanked neomycin selection cassette was also inserted into intron 11. Western blot analysis on endothelial cells derived from homozygous mice confirmed that no detectable protein was made. (J:56509)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdh5 Mutation:  5 strains or lines available
References
Original:  J:56509 Carmeliet P, et al., Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 1999 Jul 23;98(2):147-57
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory