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Targeted Allele Detail
Symbol: Utrntm1Jrs
Name: utrophin; targeted mutation 1, Joshua R Sanes
MGI ID: MGI:2148539
Synonyms: uko, utrn-
Gene: Utrn  Location: Chr10:12382188-12861735 bp, - strand  Genetic Position: Chr10, 3.77 cM
Germline Transmission:  Earliest citation of germline transmission: J:39218
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced 2.7 kb of sequence including 52 bp of the exon that encodes the beginning of the C-terminal cysteine rich region. RT-PCR analysis demonstrated that a mutant transcript carrying the deletion was made in homozygous and heterozygous mice. Western blot analysis on extracts of muscle or lung tissue derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:39218)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Utrn Mutation:  153 strains or lines available
Original:  J:39218 Grady RM, et al., Subtle neuromuscular defects in utrophin-deficient mice. J Cell Biol. 1997 Feb 24;136(4):871-82
All:  34 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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