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Lamb2tm1Jrs
Targeted Allele Detail
Nomenclature
Symbol: Lamb2tm1Jrs
Name: laminin, beta 2; targeted mutation 1, Joshua R Sanes
MGI ID: MGI:2138070
Synonyms: beta2, Lamb2-
Gene: Lamb2  Location: Chr9:108479736-108490530 bp, + strand  Genetic Position: Chr9, 59.4 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23783
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    Insertion of a neomycin cassette into the second exon of the gene. (J:23783)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lamb2 Mutation:  3 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: human congenital or idiopathic nephritic syndromes such as minimal change nephrotic syndrome (MCNS) and glomerulonephrosis (J:27732).
References
Original:  J:23783 Noakes PG, et al., Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin beta 2. Nature. 1995 Mar 16;374(6519):258-62
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory