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Apoetm1Bres
Targeted Allele Detail
Nomenclature
Symbol: Apoetm1Bres
Name: apolipoprotein E; targeted mutation 1, Jan L Breslow
MGI ID: MGI:2137814
Synonyms: apo E-, apoE-, EKO, epsilon-
Gene: Apoe  Location: Chr7:19696109-19699166 bp, - strand  Genetic Position: Chr7, 9.94 cM
Gross appearance of aortic arches of Apoetm1Bres/Apoetm1Bres, Plgtm1Jld/Plgtm1Jld and Apoetm1Bres/Apoetm1Bres Plgtm1Jld/Plgtm1Jld mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:2809
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  59 strains or lines available
Notes

In Apoetm1Bres mutant mice also carrying Csf1op, atherotic lesions of the proximal aorta were abolished or significantly reduced in size relative to Apoe mutants homozygous for the normal allele at Csf1 (J:29024).

References
Original:  J:2809 Plump AS, et al., Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992 Oct 16;71(2):343-53
All:  109 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory