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Ptger1tm1Sna
Targeted Allele Detail
Nomenclature
Symbol: Ptger1tm1Sna
Name: prostaglandin E receptor 1 (subtype EP1); targeted mutation 1, Shuh Narumiya
MGI ID: MGI:2137762
Synonyms: EP1-, Ptger1-
Gene: Ptger1  Location: Chr8:83666678-83672753 bp, + strand  Genetic Position: Chr8, 40.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70534
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin resistance cassette into the FspI site of exon 2, located immediately before the sequence encoding the first transmembrane domain. Northern blots of renal tissue did not detect Ptger1 transcript in homozygous mutant mice. (J:70534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptger1 Mutation:  16 strains or lines available
References
Original:  J:70534 Ushikubi F, et al., Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature. 1998 Sep 17;395(6699):281-4
All:  44 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory