Ptger3^tm1Sna
Targeted Allele Detail

Summary

• Symbol: Ptger3^tm1Sna
• Name: prostaglandin E receptor 3 (subtype EP3); targeted mutation 1, Shuh Narumiya
• MGI ID: MGI:2137759
• Synonyms: EP3-, EP3R^-
• Gene: Ptger3 Location: Chr3:157272459-157350392 bp, + strand Genetic Position: Chr3, 81.32 cM
• Alliance: Ptger3^tm1Sna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70534
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neomycin resistance cassette replaced 1kb of sequence containing almost all of exon 1, which encodes the region of the receptor from the amino terminus to the sixth transmembrane domain. Northern blots of renal tissue did not detect message in homozygous mutant mice. In addition, the mutation was confirmed functionally, by lack of detectable binding of [3H]-PGE2. (J:70534)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptger3^tm1Sna

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptger3 Mutation: 17 strains or lines available

References

• Original: J:70534 Ushikubi F, et al., Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature. 1998 Sep 17;395(6699):281-4
• All: 64 reference(s)