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Targeted Allele Detail
Symbol: Ptger3tm1Sna
Name: prostaglandin E receptor 3 (subtype EP3); targeted mutation 1, Shuh Narumiya
MGI ID: MGI:2137759
Synonyms: EP3-, EP3R-
Gene: Ptger3  Location: Chr3:157272459-157350392 bp, + strand  Genetic Position: Chr3, 81.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:70534
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ-neomycin resistance cassette replaced 1kb of sequence containing almost all of exon 1, which encodes the region of the receptor from the amino terminus to the sixth transmembrane domain. Northern blots of renal tissue did not detect message in homozygous mutant mice. In addition, the mutation was confirmed functionally, by lack of detectable binding of [3H]-PGE2. (J:70534)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptger3 Mutation:  10 strains or lines available
Original:  J:70534 Ushikubi F, et al., Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature. 1998 Sep 17;395(6699):281-4
All:  59 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory