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Hadhatm1Jib
Targeted Allele Detail
Nomenclature
Symbol: Hadhatm1Jib
Name: hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit; targeted mutation 1, Jamal A Ibdah
MGI ID: MGI:2137697
Synonyms: Mtpa-
Gene: Hadha  Location: Chr5:30118304-30155162 bp, - strand  Genetic Position: Chr5, 15.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69846
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 1.6kb of sequence containing exon 1, flanking 5' sequences, and part of intron 1. Northern blot analysis of total RNA did not detect mRNA in liver and heart of homozygous mutant newborn pups. Western blot analysis did not detect protein in extracts of liver and heart tissue of homozygous mutant newborn pups. (J:69846)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hadha Mutation:  9 strains or lines available
References
Original:  J:69846 Ibdah JA, et al., Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden death. J Clin Invest. 2001 Jun;107(11):1403-9
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory