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Mmetm1Cge
Targeted Allele Detail
Nomenclature
Symbol: Mmetm1Cge
Name: membrane metallo endopeptidase; targeted mutation 1, Craig Gerard
MGI ID: MGI:2137696
Synonyms: NEP-
Gene: Mme  Location: Chr3:63241537-63386030 bp, + strand  Genetic Position: Chr3, 29.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70516
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced 0.6kb of sequence containing exon 13 and part of intron 13. Northern blot analysis using a cDNA probe for the active site region, exons 14 - 20, did not detect message in renal tissue from homozygous mutant pups. (J:70516)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mme Mutation:  37 strains or lines available
References
Original:  J:70516 Lu B, et al., Neutral endopeptidase modulation of septic shock. J Exp Med. 1995 Jun 1;181(6):2271-5
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory