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Ephx1tm1Gonz
Targeted Allele Detail
Summary
Symbol: Ephx1tm1Gonz
Name: epoxide hydrolase 1, microsomal; targeted mutation 1, Frank J Gonzalez
MGI ID: MGI:2137236
Synonyms: mEH-
Gene: Ephx1  Location: Chr1:180817121-180845134 bp, - strand  Genetic Position: Chr1, 84.48 cM
Alliance: Ephx1tm1Gonz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:56886
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 0.7 kb of sequence containing part of exon 2. Northern blot analysis detected a shorter mRNA transcript produced by this allele. However, western blot analysis of extracts of liver microsomes derived from homozygous mice did not detect any encoded protein. (J:56886)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ephx1 Mutation:  30 strains or lines available
Notes
The ES cell line, purchased from Genome Systems (St. Louis), was derived from 129X1/Sv. The name of the line was not specified.
References
Original:  J:56886 Miyata M, et al., Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene. J Biol Chem. 1999 Aug 20;274(34):23963-8
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory